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Product info: Diabetes    
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the α-glucosidase inhibitors.

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How should you take Avandamet?

Do not take more or less of Avandamet than directed by your doctor. Avandamet should be taken in divided doses with meals to reduce the possibility of nausea or diarrhea, especially during the first few weeks of therapy. Avandamet may start to work within the first week or two after you begin taking it, but it can take up to 3 months before the drug's full effects are seen. Be sure to check your blood sugar as your doctor recommends.
If you miss a dose...
Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.
Storage instructions...
Store at room temperature in a tight, light-resistant container.
What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Avandamet.
Side effects may include:
Accidental injury, anemia, back pain, diarrhea, fatigue, headache, joint pain, nausea, sinus inflammation, swelling, upper respiratory infection, upset stomach, viral infection
Why should Avandamet not be prescribed?

Avandamet is processed primarily by the kidneys, and can build up to excessive levels in the body if the kidneys aren't working properly. It should be avoided if you have kidney disease or your kidney function has been impaired by a condition such as shock, blood poisoning, or a heart attack.

You should not use Avandamet if you need to take medicine for congestive heart failure.

Do not take Avandamet if you have ever had an allergic reaction to rosiglitazone or metformin.

Do not take Avandamet if you have metabolic or diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity breath).

You should not use Avandamet if you have type 1 (insulin-dependent) diabetes, or if you are already taking insulin.



 
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